解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Bacterial Type III Secretion Systems deliver effectors into host cells to manipulate cellular processes to the advantage of the pathogen. Many host targets of these effectors are found on membranes. Therefore, to identify their targets, effectors often use specialized membrane-localization domains to localize to appro...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3973
更新日期:2013-01-01 00:00:00
abstract::Electrocatalysts for oxygen reduction are a critical component that may dramatically enhance the performance of fuel cells and metal-air batteries, which may provide the power for future electric vehicles. Here we report a novel bio-inspired composite electrocatalyst, iron phthalocyanine with an axial ligand anchored ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3076
更新日期:2013-01-01 00:00:00
abstract::Modelling of non-adiabatic dynamics in extended molecular systems and solids is a next frontier of atomistic electronic structure theory. The underlying numerical algorithms should operate only with a few quantities (that can be efficiently obtained from quantum chemistry), provide a controlled approximation (which ca...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3144
更新日期:2013-01-01 00:00:00
abstract::Hallmarks of criticality, such as power-laws and scale invariance, have been empirically found in cortical-network dynamics and it has been conjectured that operating at criticality entails functional advantages, such as optimal computational capabilities, memory and large dynamical ranges. As critical behaviour requi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3521
更新日期:2013-01-01 00:00:00
abstract::Colloidal quantum dots have emerged as a material platform for low-cost high-performance optoelectronics. At the heart of optoelectronic devices lies the formation of a junction, which requires the intimate contact of n-type and p-type semiconductors. Doping in bulk semiconductors has been largely deployed for many de...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3981
更新日期:2013-01-01 00:00:00
abstract::With the development of ultrafast electron and X-ray sources it is becoming possible to study structural dynamics with atomic-level spatial and temporal resolution. Because of their short mean free path, electrons are particularly well suited for investigating surfaces and thin films, such as the challenging and impor...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2700
更新日期:2013-01-01 00:00:00
abstract::Forests are of major importance to human society, contributing several crucial ecosystem services. Biodiversity is suggested to positively influence multiple services but evidence from natural systems at scales relevant to management is scarce. Here, across a scale of 400,000 km(2), we report that tree species richnes...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2328
更新日期:2013-01-01 00:00:00
abstract::Troodontid dinosaurs share a close ancestry with birds and were distributed widely across Laurasia during the Cretaceous. Hundreds of occurrences of troodontid bones, and their highly distinctive teeth, are known from North America, Europe and Asia. Thus far, however, they remain unknown from Gondwanan landmasses. Her...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2716
更新日期:2013-01-01 00:00:00
abstract::Nitrate is both an important nutrient and a signalling molecule for plants. Although several components of the nitrate signalling pathway have been identified, their hierarchical organization remains unclear. Here we show that the localization of NLP7, a member of the RWP-RK transcription factor family, is regulated b...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2650
更新日期:2013-01-01 00:00:00
abstract::Bright sources of indistinguishable single photons are strongly needed for the scalability of quantum information processing. Semiconductor quantum dots are promising systems to build such sources. Several works demonstrated emission of indistinguishable photons while others proposed various approaches to efficiently ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2434
更新日期:2013-01-01 00:00:00
abstract::Recent density-functional theory calculations suggest that codoping TiO2 with donor-acceptor pairs is more effective than monodoping for improving photoelectrochemical water-splitting performance because codoping can reduce charge recombination, improve material quality, enhance light absorption and increase solubilit...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2729
更新日期:2013-01-01 00:00:00
abstract::The gut-derived orexigenic peptide hormone ghrelin enhances neuronal firing in the substantia nigra pars compacta, where dopaminergic neurons modulate the function of the nigrostriatal system for motor coordination. Here we describe a novel mechanism by which ghrelin enhances firing of nigral dopaminergic neurons by i...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2439
更新日期:2013-01-01 00:00:00
abstract::Several of the steps in protein synthesis on the ribosome utilize hydrolysis of guanosine triphosphate (GTP) as the driving force. This reaction is catalyzed by translation factors that become activated upon binding to the ribosome. The recently determined crystal structure of an elongation factor-Tu ternary complex b...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2741
更新日期:2013-01-01 00:00:00
abstract::An effective way to improve polymer solar cell efficiency is to use a tandem structure, as a broader part of the spectrum of solar radiation is used and the thermalization loss of photon energy is minimized. In the past, the lack of high-performance low-bandgap polymers was the major limiting factor for achieving high...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2411
更新日期:2013-01-01 00:00:00
abstract::The direct transformation of cellulose, which is the main component of lignocellulosic biomass, into building-block chemicals is the key to establishing biomass-based sustainable chemical processes. Only limited successes have been achieved for such transformations under mild conditions. Here we report the simple and ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3141
更新日期:2013-01-01 00:00:00
abstract::Cambodia harbours a variety of aboriginal (and presumably ancient) populations that have largely been ignored in studies of genetic diversity. Here we investigate the matrilineal gene pool of 1,054 Cambodians from 14 geographic populations. Using mitochondrial whole-genome sequencing, we identify eight new mitochondri...
journal_title:Nature communications
pub_type: 历史文章,杂志文章
doi:10.1038/ncomms3599
更新日期:2013-01-01 00:00:00
abstract::Laboratory spectroscopy of atomic hydrogen in a magnetic flux density of 10(5) T (1 gigagauss), the maximum observed on high-field magnetic white dwarfs, is impossible because practically available fields are about a thousand times less. In this regime, the cyclotron and binding energies become equal. Here we demonstr...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2466
更新日期:2013-01-01 00:00:00
abstract::Insulin-like growth factor 1 (IGF-1) is a critical regulator of many physiological functions, ranging from longevity to immunity. However, little is known about the role of IGF-1 in natural killer cell development and function. Here, we identify an essential role for IGF-1 in the positive regulation of human natural k...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2484
更新日期:2013-01-01 00:00:00
abstract::Quasicrystals, materials with aperiodic long-range order, have been found in intermetallics, soft materials such as colloids and supermolecules, and also in two-dimensional monolayer films. Here we present the first example of three-dimensional growth of a single-element quasicrystalline film. Using a hitherto unexplo...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3715
更新日期:2013-01-01 00:00:00
abstract::Nematode neurons generally produce graded potentials instead of action potentials. It is unclear how the graded potentials control postsynaptic cells under physiological conditions. Here we show that postsynaptic currents frequently occur in bursts at the neuromuscular junction of Caenorhabditis elegans. Cholinergic b...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2925
更新日期:2013-01-01 00:00:00
abstract::Graphene has various potential applications owing to its unique electronic, optical, mechanical and chemical properties, which are primarily based on its two-dimensional nature. Graphene-based vertical devices can extend the investigations and potential applications range to three dimensions, while interfacial propert...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2935
更新日期:2013-01-01 00:00:00
abstract::Heartbeat is required for normal development of the heart, and perturbation of intracardiac flow leads to morphological defects resembling congenital heart diseases. These observations implicate intracardiac haemodynamics in cardiogenesis, but the signalling cascades connecting physical forces, gene expression and mor...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2978
更新日期:2013-01-01 00:00:00
abstract::A key mechanism of bacterial resistance to macrolide antibiotics is the dimethylation of a nucleotide in the large ribosomal subunit by erythromycin resistance methyltransferases. The majority of erm genes are expressed only when the antibiotic is present and the erythromycin resistance methyltransferase activity is c...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2984
更新日期:2013-01-01 00:00:00
abstract::Cladodontomorph sharks are Palaeozoic stem chondrichthyans thought to go extinct at the end-Permian mass extinction. This extinction preceded the diversification of euselachians, including modern sharks. Here we describe an outer-platform cladodontomorph shark tooth assemblage from the Early Cretaceous of southern Fra...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3669
更新日期:2013-01-01 00:00:00
abstract::Fluorescence imaging is one of the most versatile and widely used visualization methods in biomedical research. However, tissue autofluorescence is a major obstacle confounding interpretation of in vivo fluorescence images. The unusually long emission lifetime (5-13 μs) of photoluminescent porous silicon nanoparticles...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3326
更新日期:2013-01-01 00:00:00
abstract::A cloak that can hide living creatures from sight is a common feature of mythology but still remains unrealized as a practical device. To preserve the wave phase, the previous cloaking solution proposed by Pendry and colleagues required transformation of the electromagnetic space around the hidden object in such a way...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3652
更新日期:2013-01-01 00:00:00
abstract::Environmental challenges to plants typically entail retardation of vegetative growth and delay or cessation of flowering. Here we report a link between the flowering time regulator, GIGANTEA (GI), and adaptation to salt stress that is mechanistically based on GI degradation under saline conditions, thus retarding flow...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2357
更新日期:2013-01-01 00:00:00
abstract::Inorganic polyphosphate is known to be present in the mammalian brain at micromolar concentrations. Here we show that polyphosphate may act as a gliotransmitter, mediating communication between astrocytes. It is released by astrocytes in a calcium-dependent manner and signals to neighbouring astrocytes through P2Y(1) ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2364
更新日期:2013-01-01 00:00:00
abstract::Genetic ablation of endothelial focal adhesion kinase (FAK) can inhibit pathological angiogenesis, suggesting that loss of endothelial FAK is sufficient to reduce neovascularization. Here we show that reduced stromal FAK expression in FAK-heterozygous mice unexpectedly enhances both B16F0 and CMT19T tumour growth and ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3020
更新日期:2013-01-01 00:00:00
abstract::Electron motion in chemical bonds occurs on an attosecond timescale. This ultrafast motion can be driven by strong laser fields. Ultrashort asymmetric laser pulses are known to direct electrons to a certain direction. But do symmetric laser pulses destroy symmetry in breaking chemical bonds? Here we answer this questi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3177
更新日期:2013-01-01 00:00:00
abstract::The ability to quickly spread a liquid across a surface and form a film is fundamental for a diverse range of technological processes, including printing, painting and spraying. Here we show that liquid dielectrophoresis or electrowetting can produce wetting on normally non-wetting surfaces, without needing modificati...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2619
更新日期:2013-01-01 00:00:00
abstract::Selected groups of peptides, including those that are presented by major histocompatibility complex (MHC) proteins, have been proposed to transmit information to the olfactory system of vertebrates via their ability to stimulate chemosensory neurons. However, the lack of knowledge about such peptides in natural source...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2610
更新日期:2013-01-01 00:00:00
abstract::Despite rapid advances in genome engineering technologies, inserting genes into precise locations in the human genome remains an outstanding problem. It has been suggested that site-specific recombinases can be adapted towards use as transgene delivery vectors. The specificity of recombinases can be altered either wit...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3509
更新日期:2013-01-01 00:00:00
abstract::Hedgehog (Hh) signalling regulates embryonic development and adult tissue homoeostasis. Mutations of its pathway components including Suppressor of Fused (Sufu) and Gli/Ci predispose to cancers and congenital anomalies. The Sufu-Gli protein complex occupies a central position in the vertebrate Hh signalling pathway, e...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3608
更新日期:2013-01-01 00:00:00
abstract::Insulin resistance is closely associated with obesity and is one of the earliest symptoms of type-2 diabetes. Endothelial cells are involved in the pathogenesis of insulin resistance through their role in insulin delivery and adipose tissue angiogenesis. Here we show that Ecscr (endothelial cell surface expressed chem...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3389
更新日期:2013-01-01 00:00:00
abstract::Despite the lack of a layered neocortex and fundamental differences in endbrain organization in birds compared with mammals, intelligent species evolved from both vertebrate classes. Among birds, corvids show exceptional cognitive flexibility. Here we explore the neuronal foundation of corvid cognition by recording si...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3878
更新日期:2013-01-01 00:00:00
abstract::Long-term depression (LTD) underlies learning and memory in various brain regions. Although postsynaptic AMPA receptor trafficking mediates LTD, its underlying molecular mechanisms remain largely unclear. Here we show that stargazin, a transmembrane AMPA receptor regulatory protein, forms a ternary complex with adapto...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3759
更新日期:2013-01-01 00:00:00
abstract::The Johnson-Kendall-Roberts theory is the basis of modern contact mechanics. It describes how two deformable objects adhere together, driven by adhesion energy and opposed by elasticity. Here we characterize the indentation of glass particles into soft, silicone substrates using confocal microscopy. We show that, wher...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3728
更新日期:2013-01-01 00:00:00
abstract::The mobility of drops on surfaces is important in many biological and industrial processes, but the phenomena governing their adhesion, which is dictated by the morphology of the three-phase contact line, remain unclear. Here we describe a technique for measuring the dynamic behaviour of the three-phase contact line a...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2482
更新日期:2013-01-01 00:00:00
abstract::Single-nucleotide substitutions are a defining characteristic of cancer genomes. Many single-nucleotide substitutions in cancer genomes arise because of errors in DNA replication, which is spatio-temporally stratified. Here we propose that DNA replication patterns help shape the mutational landscapes of normal and can...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2502
更新日期:2013-01-01 00:00:00